Which of the following statements is true: Question 5 options: There is a positi

Question

Which of the following statements is true:

Question 5 options:

There is a positive correlation between yield and biotin concentration

Biomass-derived insoluble proteins include starch, hemicelluloses, and cellulose

Lactic acid is produced in fermentation by Lactococcus spheriensis.

Which of the following options provides capital that is non-dilutive and a stakeholder that is not seeking an exit strategy:

Question 3 options:

Venture capital funding

Seed Investment

Cash from angel Investors

Employees paid with stock

Government grants

Which of the following is not a requirement for a patent:

Question 4 options:

It must be useful for something

It should be a marketable product in the country of application

No-one should have done it before

It should describe how someone else could do it

It should not be obvious

Which of the following would not be one of the criteria for strain improvement:

Question 8 options:

Tolerance of high salt concentrations

Tolerance of antifoams

Improved cysteine synthesis

Improved glucose and glucuronic acid regulation

Tolerance of high levels of carbon dioxide

Pharmacopoeia grade lactic acid is:

Question 7 options:

Meets the specification of U.S.P [United States Pharmacopoeia]

Made using bacteria that contain racemates

Meets the specifications of the US Patent and Trademark Office's (USPTO) definition of pharmaceutical-grade products

Only produced from chemical synthesis

Only derived from glucose as the carbon source

An advantage of shake-flask fermentation is:

Question 9 options:

No buffer is necessary

Antifoam is not required

pH can be controlled

In-process sampling is easy

Very uniform growth

Which one of the following is not a benefit of enzyme hydrolysis of penicillin / cephalosporins:

Question 10 options:

All variants can be hydrolyzed easily

Elimination of alcohol solvents

Reduced costs

Improved yields

Neutral pH reactions and ambient temperatures

Which of the following would have "attractive growth potential":

Question 12 options:

A new HIV treatment in Russia

A new anti-ulcer medication in Japan

A new asthma drug in the U.S.

A new rheumatoid arthritis drug in the U.S.

A new drug for diabetes in France

How many of the top 10 largest initial adjudicated damages awards from patent litigation from 2005 - 2013 involved biotech / pharmaceutical companies:

Question 13 options:

8

4

2

6

10

Which of the following has a maximum lifespan of 20 years:

Question 14 options:

FDA approval

A tradmark

Copyright

Trade secret

A patent

Which of the following would not be consider a key term in a intellectual property licensing agreement:

Question 15 options:

Exclusivity to practice in a geographical market

Exclusivity to practice in a market segment

The term of the agreement

An agreement not to sue

Transfer of rights to a patent

Which of the following is not an evolvable enzyme property:

Question 16 options:

Stability

Catalysis of a different reaction

Substrate specificity

Enantioselectivity

Activity

Which of the following is not an enzyme used in a diagnostic assay:

Question 17 options:

Phytase

Gluocose oxidase

Urease

Beta-galactosidase

Peroxidase

Which is the following is not an FDA-approved recombinant protein drug:

Question 18 options:

Erythropoietin

Insulin

Penicillin

Interferon-gamma

DNase

Which of the following statements is incorrect:

Question 19 options:

A biosimilar needs to be produced in the same facility as a previously approved biologic

A biosimilar need to have the same purity as a previously approved biologic

If different excipients from an approved biologic are used, their interaction with a biosimilar need to be characterized.

A biosimilar need to have the same safety profile as a previously approved biologic

A biosimilar need to have the same potency as a previously approved biologic

Which of the following is not a phase in bacterial fermentation:

Question 20 options:

Linear phase

Stationary phase

Log phase

Death phase

Lag phase

a) In 2007, worldwide annual production of citric acid was over a million metric tons b)

There is a positive correlation between yield and biotin concentration

c)

Biomass-derived insoluble proteins include starch, hemicelluloses, and cellulose

d) Changzhou Changmao Biochemical Engineering Co. Ltd. specializes in manufacturing C-4 series organic acids such as p-Toluenesulfonic acid e)

Lactic acid is produced in fermentation by Lactococcus spheriensis.

Explanation / Answer

5. The correct answer is option a, c, d and e.

option a because in 2007, worldwide annual production of citric acid was approximately 1,700,000 Metric ton.

option c because biomass is the solar energy which is stored in pant and animal in the form of chemical. The components of biomass include cellulose, hemiocelluloses, lignin, extractives, lipids, proteins, simple sugars, starches,water and other compounds.

option d because the company is specialized in manufacturing and szelling C-4 series organic acids and chiral products. The main products are Aspartame, L-Malic acid, DL-Malic acid, L(+)-Tartaric acid, DL-Tartaric acid, L-Aspartic acid, Fumaric acid, Maleic acid, Maleic anhydride, phenylalanine aspartame diethyl d tartrate polyaspartic acid, etc.

option e because lactic acid are produced by the fermentation of plant and animal products by lactic acid bacteria because their properties contributes to food production or conversion.

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