Histamine is a chemical substance released in inflammatory and allergic response

Question

Histamine is a chemical substance released in inflammatory and allergic responses. The histamine H1 receptor is a G protein-coupled receptor that activates phospholipase C in response to the binding of histamine. Place the items in the correct order to illustrate the process of histamine signal transduction from the H1 receptor. Calcium ions flow through the ligand-gated ion channel Calcium ions activate a protein, leading to a cellular response Calcium ion concentration increases in the cytosol. binds to a ligand-gated ion channel in the ER membrane Enzyme cleaves PIP2, forming DAG and lP3

Explanation / Answer

Process of Histamine signal transduction from the H1 receptors takes place as per the sequence given below.

1. Enzyme cleaves PIP2, forming DAG and IP3

2. IP3 binds to a ligand-gated ion channel in the ER membrane.

3. Calcium ions flow through the ligand-gated ion channel.

4. Calcium ion concentration increases in the cytosol.

5. Calcium ions activate a protein, leading to a cellular response

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