Q: The porcine stress syndrome, where pigs die suddenly on their way to the slau
ID: 47848 • Letter: Q
Question
Q:
The porcine stress syndrome, where pigs die suddenly on their way to the slaughter house, is due to a genetic defect in metabolism. The symptoms are a dramatic rise in body temperature and both metabolic and respiratory acidosis, which occur in affected pigs that are exposed to high-stress situations. Uncontrolled futile cycling, in which ATP hydrolysis is greatly accelerated, is thought to be the basis for the rise in body temperature. Which of the following pairs of enzymes, assuming both are fully activated, would produce a futile cycle?
PLEASE PROVIDE AN EXPLANATION
A. Glucose 6-phosphatase: fructose 1,6-bisphosphatase.
B. Phosphofructokinase-1: phosphofructokinase-2
C. Glycogen phosphorylase kinase: glycogen synthase
D. Pyruvate carboxylase: phosphoenolpyruvate carboxykinase
E. Glycogen phosphorylase: hexokinase
A. Glucose 6-phosphatase: fructose 1,6-bisphosphatase.
B. Phosphofructokinase-1: phosphofructokinase-2
C. Glycogen phosphorylase kinase: glycogen synthase
D. Pyruvate carboxylase: phosphoenolpyruvate carboxykinase
E. Glycogen phosphorylase: hexokinase
Explanation / Answer
B. Phosphofructokinase-1: phosphofructokinase-2
Halothane gene is known as Porseline stress syndrome (PSS) because it causes Porseline stress syndrome (PSS), this gene is expressed in the presence of anasthetic halothane gas. Heigher rate of glycolysis is observed in the pigs with PSS, which may cause sudden death in affected animals. The mechanism is activation of AMP-activated protein kinase (AMPK) triggers phosphofructokinase-2 (PFK-2) pathway, which further catalyzes the production of Fructose-2,6-diphosphate, which is a potent allosteric activator of phosphofructokinase-1 (PFK-1). PFK-1 is the rate limiting enzyme in glycolysis. Higher PFK-1 activity causes enhance glycolysis and the same is also detected in postmortem muscle of halothane carrier pigs.
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