Ultrame 2:25 PM 7496 . instructure-uploads-2.s3.amazonaws.com C. Using a flow di
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Ultrame 2:25 PM 7496 . instructure-uploads-2.s3.amazonaws.com C. Using a flow diagram demonstrate each of the three membrane receptor proteins. I have completed the first one for you. Signal molecule (ligand) binds to membrane récèptor protei receptor protein changes shape opening the "gate ons flow into the cell increase in ion concentration inside the cell initiates transduction. act as which controls which genes are transcribed into mRNA. F. Briefly describe which signal molecules (ligands) bind with the appropriate receptor proteins. I have again done the first one for you. Ion-Channel-linked Receptor binds with: neurotransmitters (acetylocholine, norepinephrine, dopamine serotonin etc.) G-Protein-Linked Receptor binds with: Enzyme-linked Receptor bind with Intracellular Protein Receptors binds with: hormonesExplanation / Answer
G-protein linked receptor:- ligand binds to G-protein coupled receptor---> receptor changes its shape ------->G- protein becomes a guanine nucleotide exchange factor------> exchanges its bound GDP for GTP ------>alpha subunit of G-protein together with GTP dissociate from beta and gamma subunit ----->further intracellular signalling process continues with the dissociated alpha subunit having GTP.
Enzyme linked receptor:- ligand binds to receptor on extracellular domain---------> conformational change in the receptor------------>enzymatic activity occurs on the intracellular side
E. Intracellular protein receptors act as messengers, which control which genes are transcribed into proteins.
F. G-protein linked receptors binds with neurotransmitters (serotonin, dopamine, GABA, glutamate), odorants, pheromones, inflammatory mediators.(Actually GPCR are involved in a variety of physiological roles including the five senses, homeostasis, cell density testing etc.)
Enzyme linked receptors bind with growth factors and hormones (The most numerous of all enzyme linked receptors is receptor tyrosine kinase. It binds with growth factors and hormones including Platelet derived growth factor, hepatocyte growth factor etc..)
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