Allostery is observed when a protein has a) one binding site where multiple liga

Question

Allostery is observed when a protein has

a) one binding site where multiple ligands can bind

b) more than one binding site

c) multiple subunits each with a ligand binding site

d) multiple ligand binding sites that interact through conformational change

While the binding of O2 to myoglobin as a function of [O2] is described by a simple curve, the binding to hemoglobin is described by a more complex ___ curve.

a) sigmoidal; hyperbolic

b) hyperbolic; sigmoidal

c) exponential; hyperbolic

d) sigmoidal; bell shaped

e) hyperbolic; concave

The SYMMETRY model of ligand binding requires that:

a) all ligand binding site spontaneously adopt the high affinity conformation together

b) a ligand must be bound to one of the ligand binding sites

c) more than one ligand binding site adopt the high affinity conformation

d) ligands only interact with the high affinity state

The SEQUENTIAL model of ligand binding requires that:

a) binding of a ligand induces a conformational change in other ligand binding sites

b) ligand binding sites spontaneously adopt a high affinity conformation

c) all ligand binding sites adopt a high affinity state simultaneously

d) ligand binding does not necessarily cause a change in conformation

Allostery is observed when a protein has

Explanation / Answer

Allostery is observed when a protein has

ans: d) multiple ligand binding sites that interact through conformational change

While the binding of O2 to myoglobin as a function of [O2] is described by a simple curve, the binding to hemoglobin is described by a more complex ___ curve.

ans: hyperbolic; sigmoidal

The SYMMETRY model of ligand binding requires that:

ans: d) ligands only interact with the high affinity state

The SEQUENTIAL model of ligand binding requires that:

ans: d) ligand binding does not necessarily cause a change in conformation

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