5. The Eta toxin produced by Clostridium haemolyticum (a species of anaerobic ba

Question

5. The Eta toxin produced by Clostridium haemolyticum (a species of anaerobic bacteria) is a tropomyosinase (an enzyme that destroys tropomyosin). (Assume all the tropomyosin are destroyed)

a) What would be the initial effect of treating a vertebrate skeletal muscle with Eta toxin? Explain.

b) Would this effect continue if the muscle were continuously exposed to Eta toxin over many hours?

Explain why or why not.

6. Certain mutations in the genes coding for the ryanodine receptor can result in susceptibility to a disease called malignant hyperthermia. The symptoms of this disease are muscular rigidity, increased metabolic rate and increased body temperature.

What type of change in function of RyR could cause muscular rigidity (excessive muscle contraction)? Explain.

Explanation / Answer

5. a) No contraction

b) On prolonged exposure, can lead to paralysis.

6) RYR receptor is responsible for movement of Ca2+ ions from lumen to cytoplasm of SER. This is responsible for muscle contraction. Thus mutation will prevent muscles from contracting

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