Assume you have a membrane-bound compartment surrounded by a lipid bilayer which

Question

Assume you have a membrane-bound compartment surrounded by a lipid bilayer which has a glucoseselective uniport. The space inside the compartment has a volume of 1000 µl. The space outside the compartment has a space of 1000 liters. If the extracellular glucose concentration in the outside space is 100 mM and the space inside the compartment is 10 mM, which direction will the glucose go? At equilibrium, what will the glucose concentration be inside the membrane-bound compartment (your answer needs to be within 10% of the correct value!)? What will the concentration be outside the membrane-bound compartment (your answer needs to be within 10% of the correct value!)?

Explanation / Answer

inside = 0.001 L, Concentration = 10 M/ L

outside = 1000 L, concentration = 10 * 10-4 M/L.

This means inside glucose concentration is more. So the movement will be from inside to outside. Now here in facilitated transport, where polar molecule is needed to be transported, concentration would be same at equilibrium (inside and outside).

Thus, total glucose = 10 + 0.0001 = 10.0001 M/L

At equilibrium, Ci = Co = 5.00005 M/L.

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