Ciprofloxacin (Cipro) is a wide?spectrum antibiotic that inhibits bacterial form

Question

Ciprofloxacin (Cipro) is a wide?spectrum antibiotic that inhibits bacterial forms of topoisomerase. It was
widely known 10 years ago as the antibiotic that was being stockpiled in case of a bioterrorism attack with
anthrax. Now it is prescribed for severe, but common, bacterial infections on a fairly regular basis.
a. What is topoisomerase and what is its function in DNA replication?
b. If a patient with a bacterial infection is treated Cipro, what will be the likely effects on the
bacterial infection? In your response, cover all (1) the specific effects on the bacterial DNA (and reasons
for those effects), (2) the effects on the bacteria as a whole, and (3) the effects on the patient's
infection

Explanation / Answer

a. DNA strandforms negaitve or positive supercoild due to the unwinding of the tamplets for replication, Topioisomarase removes these supercoils without removing the nicks on the DNA. it cuts one of the DNA strand and generates a covalent phosphoester bond between the 5 phosphate on the DNA and a tyrosine residue in the enzyme. the DNA strand not seals moves through the break. again it reseals the DNA.

b.ciprofloxacin functions by inhibiting the enzme DNA gyrase, and topoisomerase IV andenzymes required to separate bacterial DNA. DNA gyrase is a type II topoisomerase, thus ciprofloxacin ihibits cell division.

ciprofloxacin rapidly distributes into the tissues of the patient after administration.ciprofloxacin and other fluoroquinoloneshas been safely recommended for in urinary tract infections. it is know for its resistance to number of bacterial pathogens like enterococci, Streptococcus pyogenes and Klebsiella pneumoniae.

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