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Bookmarks Tools Window Help Chegg Study IGuided solu- x ttps:llsession masteringchemistry.com/myetitemviewmoffset-next&assignmentPr; c q Search Spring 2017 TITH 1:30-2:45 Interactive Foundation Figure 1-3: Regulation of Enzyme Activity e previous l 6 of 7 next ords in the left column to the appropriate blanks in the sentences on the right, Reset Help in proteolytic cleavage, the precursor molecule caled a(n) is activated through its deavage by a product inhibition Reversible inhibitor relies on the low binding energies of which allow for the rapid binding and release aymogen (or Proenryme) of small molecules. occurs when the product of an enzymatic reaction can bind to-and inhbit-the activityof the enzyme feedback regulation onentimes a pathway wth multiple enzymes is regulated at tsfirststop by the binding of a downstream product in this scenario, termed the downstream product may look very diferentfrom the substratefo the frst enzyme in the pathway (that which isregulated) is a reversible covalent modifoaten in which a phosphate group is attached to an enzyme to regulate its activity. This modroaton is typically at an alcohol, such as that found on serine, threonine, or tyrosine. is a term for when the binding of one molecule induces a conformational change in the enzyme such thata econd binding this tered

Explanation / Answer

1) In proteolytic cleavage the precursor molecule called Zymogen (proenzyme) is activated though it's cleavage by proteolytic enzyme.

2) reversible inhibition relies on non - covalent interactions, th allow binding energies of which allows for the rapid binding and release of small molecules.

3) Product inhibition occurs when the product of an enzyme can bind to and inhibit the activity of the enzyme that produced it.

4) Often times a pathway with multiple enzymes is regulated at its first step by the binding of downstream product. In the scenario termed feedback inhibition, the downstream product may look very different from the substrate for the first enzyme in the pathway ( that which is regulated)

5)Phosphorylation is a reversible covalemt modification in which a phosphate group is attached to an enzyme to regulate it's activity. The modification is typically at alcohol such that as found in serine, thronine and tyrosin.

6) Allosteric regulation is the term when binding of one molecule induces a conformational change in the enzyme such that a second binding site is also altered

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