An individual with retinoblastoma has no functional Rb protein. This means that

Question

An individual with retinoblastoma has no functional Rb protein. This means that

E2F will be inhibited and the cell will continuously divide

E2F will not be inhibited and the cell will continuously divide

the Rb gene has mutated into a proto-oncogene

the Rb gene has mutated into a tumor supressor gene

E2F will be inhibited and the cell will continuously divide

E2F will not be inhibited and the cell will continuously divide

the Rb gene has mutated into a proto-oncogene

the Rb gene has mutated into a tumor supressor gene

Explanation / Answer

B) E2F will not be inhibited and the cell will continuously divide

Rb restricts the cell's ability to replicate DNA during cell division cycle.

Rb binds and inhibits the E2F transcription factors; required for cell cycle progression from G1 phase to S phase.

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