CO is a colorless, odorless toxic gas.. It binds at the O2 binding site in Hb 20

Question

CO is a colorless, odorless toxic gas.. It binds at the O2 binding site in Hb 200 times more tightly than O2. If 1 of the 4 sites in Hb is occuped by a CO molecule, O2 is poorly released at the other 3 binding sites.

A) because of sequential model of allosterism, all very tight binding of CO must then force the T state in the other subunits

B) very tight binding of CO forces the prevents equilibrium that favors R state

C) very tight binding of CO displaces CO2

D) very tight binding of CO shifts the Hb binding curve to the left

Explanation / Answer

B) very tight binding of CO forces the prevents equilibrium that favors R state

Hb has four subunits,    each one binds with one molecule of O2

totally four molecule of O2 by one Hb

however one CO is attached with Hb,     other three sites bind with O2 and it is not equilbrium

( it should be released once HB reached the cell)

Thus whole O2 transport is affected by the CO

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