Colon cancer is caused by the accumulation of multiple gene mutations that resul

Question

Colon cancer is caused by the accumulation of multiple gene mutations that result in uncontrolled cell division and growth. Arrange the following steps of colon cancer progression. Colon tissue is initially healthy. Polyps or early adenomas are formed by mutations in APC. Activating ras mutations gives rise to intermediate adenomas. Cancerous adenomas are generated by mutations in p53. Cancerous adenomas become metastatic by unknown mutations, Late adenomas are formed by the inactivation of DCC and Smad4. Colon cancer invades neighboring tissues

Explanation / Answer

Colon tissue is initially healthy

Polyps or early adenomas are formed by mutations in APC

Activating ras mutations gives rise to intermediate adenomas.

Late adenomas are formed by the inactivation of DCC and Smad4

Cancerous adenomas are generated by mutations in p53

Cancerous adenomas become metastatic by unknown mutations

Colon cancer invades neigboring tissues

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