**Could not get photo to rotate..** Question is asking to provide an example of
ID: 497308 • Letter: #
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Question is asking to provide an example of a drug that corresponds to each of the receptor sites. Then an explantion as how that drug can interact with each receptor site given.
3) (10 pts) Below are the binding of two different receptors called and DRJ1B. The natural ligand (messenger) for both receptors is shown below as well. n your position as a medicinal chemist you have been asked to design a drug that would be specific for and one that wou be activation of DRJ1A DRJ1B. Phe Val Phe Gln OH backbone Natural Messeng carbonyl Asp Receptor DRJ1A Receptor DRJ1B A) Provide an example of each drug you designed and discuss your rationale relative to the x fene. Gr structure of the natural messenger and its interactions with both receptors. of DKJIAExplanation / Answer
Solution:
As per the statement the natural messenger contains phenolic -OH group which is highly reactive to the receptor site activation, in receptor DRJ1A the competion for site binding is experienced from keto,carboxylic and amino groups as per the natural messenger molecular arrangement it is more prone to attach with Gln (=O)-NH2 group as they experience more stability by tautomerism while in receptor DRJ1B is more prone to attch with Asp (carboxyl) group because of their reactivity with -OH.
Based on the binding the more stable receptor binding can be expected only from DRJ1A rather than DRJ1B, hence as a medicinal chemist an good site for activation is Gln for DRJ1A and Asp for DRJ1B.
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