In constructing an oligonucleotide probe based on informationfrom a protein\'s s

Question

In constructing an oligonucleotide probe based on informationfrom a protein's sequence, one often chooses (if possible) regionsof a sequence containing tryptophan or methionine residues.Why?
a. The synthesis of most proteins starts with methionineor a derivative thereof, so a methionine codon assures one willstart at the beginning of the gene.
b. These two amino acids are both encoded by multiplecodons such that the degeneracy of the genetic code makes itpossible for a number of sequences to recognize and bind to thetarget sequence.
c. As these two amino acids have only one codon, theoligonucleotide probe will have a greater specificity for the DNAfragment being sought.

Explanation / Answer

The answer is C. Both methionine and tryptophan have only one codon each so theoligonucleotide probe will have a greater specificity for the DNAfragment being sought. Methionine codon is AUG Trp is UGG

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