Given the following protein sequences (one letter code) , determine the type of

Question

Given the following protein sequences (one letter code), determine the type of DNA mutation (be very specific) that caused the change (as compared to wild type) and explain what the resulting change to the mutant protein (be specific). In addition, for full credit you must give the DNA coding sequence for each protein.

NOTE – there is only “1” correct DNA sequence for the wild type coding strand!If you have a choice of nucleotides, pick the one that forms the most hydrogen bonds.

wild-type: M-Y-H-A-P-P-Y-P-I-G-stop

mutant 1: M-Y-H-A-P-P-stop

mutant 2: M-Y-N-A-P-P-Y-P-I-G-stop

mutant 3: M-Y-P-I-G-stop

mutant 4: M-Y-M-Y-M-Y-H-A-P-P-Y-P-I-G-stop

mutant 5: M-Y-T-R-A-P-I-S-Y-R-I-….

Explanation / Answer

mutant 1 ---- deletion

mutant 2 ------- displacement

mutant 3 ----- deletion

mutant 4 -------- duplication

mutant 5 ---- insertion.

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