Diamminedichloroplatinum (II) is a metal complex that can be synthesized in one

Question

Diamminedichloroplatinum (II) is a metal complex that can be synthesized in one of two isomeric forms. The formulas are the same, but the arrangement of atoms in each molecule is different As a result, the two isomers show different physical and chemical properties. For example, the cis isomer is a potent treatment for some type of cancers; the trans isomer is ineffective as an anticancer drug. a) Which isomer is overall more stable at 25 degree C, cis- or trans- ? b) Calculate an equilibrium constant for the isomerization reaction that interconverts cisplatin and its trans isomer.

Explanation / Answer

A) Trans-platin is more stable than cis-platin at 25 oC.

B) cis-platin <---------------> trans-platin

   Gorxn = Gof of products - Gof of reactants

              = Gof of trans-platin - Gof of cis-platin

              = -222.8 kJ/mol - (-480.3 kJ/mol)

              = + 257.5 kJ/mol

              = 257500 J/mol

The relation between Go and Keq is given by

  Go = -RT In Keq      where R = universal gas constant = 8.314 J/K/mol

T = 25oC = 298 K

Keq = e^-(Go/RT)

      = e^-(257500 J/mol/8.314 J/K/mol x 298 K)

     = 8.92 x 10-46

Therefore,

Equilibrium constant = 8.92 x 10-46

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