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After spending four years in college earning her degree, Shannon land her first

ID: 504074 • Letter: A

Question

After spending four years in college earning her degree, Shannon land her first job with ACME Pharmaceuticals. Right away they put her to work finding a cure for the common cold. While performing her first experiment, she finds that she3 needs to buffer a certain reaction at a pH of 3.7. Fortunately, she paid attention in her Chemistry 142 class and set out to prepare the buffer. Using the information given below, describe how she could prepare the best buffer for his requirement. Be specific and clear, showing amounts or reagents.

Explanation / Answer

The pH target is 3.7

so

we need a pKa value near that in order to form a buffer

since

pH = pKa + log(A-/HA)

so

pKa which best suits this is

1.8*10^-4 from formic acid

pKa = -log(1.8*10^-4) = 3.74

which is the nearest value

So we will need:

sodium formate + formic acid in order to create the buffer

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