In conventional peptide synthesis, the nitrogen of a given amino acid must be de

Question

In conventional peptide synthesis, the nitrogen of a given amino acid must be deactivated or blocked while the carboxyl group is activated. Which of the following reagents is used to protect the amino group of an amino acid? A) di-tert-butyl dicarbonate B) dicyclohexylcarbodiimide C) ninhydrin D) trifluoroacetic acid E) phenylisothiocyanate In peptide synthesis, give the use of dicyclohexylcarbodiimide. A) activates the carboxyl group of an amino acid B) protects the carboxyl group of an amino acid C) protects the amino group of an amino add D) activates the amino group of an amino acid E) removes the protecting group on the N terminal amino acid

Explanation / Answer

Answer:-

5. A). di-tert- butyle dicarbonate.

This group is used to protect N terminal of an amino acid because it is a tert-butyl ester which hydrolysed easily.

6. A). Activates the carboxyl group of an amino acid.

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