At lower concentration of glucose enzyme will phosphorylate glucose. a. Hexokina

Question

At lower concentration of glucose enzyme will phosphorylate glucose. a. Hexokinase b. Glucokinase Hexokinase has km than glucokinase. a. Lower b. Higher The following is true about the step catalyzed by PFK1. a. It is first irreversible step b. It catalyzes synthesis of Fructose1-6 bisphosphate c. At this step the pathway is committed to glycolysis d. It is a control point for regulation of the glycolysis pathway e. All of the above PFK-1 is inhibited during a. Glycolysis b. Gluconeogenesis The following products can be formed from pyruvate in a cell a. Lactate b. Acetyl CoA c Ethanol d, Oxaloacetate e. All of the above The following are products of pyruvate kinase. a. Phosphoenolpyruvate b. Pyruvate c. ATP

Explanation / Answer

9. Hexokinase and glucokinase are isoenzymes and both phosphorylates glucose. However glucokinase is present only in liver whereas hexokinase is present throughout all tissues including liver. Hexokinase is therefore active at low concentration of glucose because of its availability throughout the body. Hexokinase has low Km value which signifies higher affinity for glucose. So, hexokinase phosphorylates glucose even at very low glucose concentration.

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