The first reaction in glycolysis it the phosphorylation of glucose: Pi + glucose

Question

The first reaction in glycolysis it the phosphorylation of glucose: Pi + glucose rightarrow glucose-6-phosphate + H_2O. This is a thermodynamically unfavorable process, with delta G degree = +13.8kJ/mol. The reaction is coupled to ATP hydrolysis to give the overall reaction ATP + glucose rightarrow glucose-6-phosphate + ADP + H^+. If delta G degree of ATP hydrolysis is -32.2 kJ/mol, what is delta G degree for the coupled reaction? 46 kJ/mol -18.4 kJ/mol -32.2 kJ/mol 18.4 kJ/mol fluoride is a known inhibitor of enolase. Drinking fluoridated water provides fluoride at a level that inhibits oral bacteria enolase activity. Disruption of the bacteria's glycolytic pathway, and this its normal metabolic functioning prevents dental caries from forming Which of the following compounds would you expect to increase in concentration in bacterial cytosol following the addition of fluoride? 2-Phosphoglucerate Glucose Phosphoenolpyruvate Pyruvate Does glue oncogenesis require oxygen (02)? No, carbon di oxide is the only gas that is a substrate for gl uconeogenesis. No, oxygen(2) is not a substrate for any of the enzyme-catalyzed reactions. Yes, oxygen is required to reduce NAD+ to NADH in gluconeogenesis. Yes, gluconeogenesis requires oxygen (O2)to make ATP. The process by which ATP is formed directly in glycolysis is: Substrate level phosphorylation ATP hydrolysis Oxidative phosphorylation Isomerization None of above Which enzyme catalyzed reaction in gluconeogenesis generates NADH? The reaction catalyzed by pyruverte carboxylase The reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase The reaction catalyzed by glucose-6-phosphertase The reaction catalyzed by fructose-1.6, bisphosphate None of the listed enzyme catalyzed reactions in gluconeogenesis generates NADH. Which statement explains why many biochemical processes are carried out via multi-step pathways rather than by single-step reactions? Multi-step path ways allow for more control points to regulate biochemical processes. Single step pathways are easier to control There is not sharing of intermediates between pathways There is no control over the amounts of energy that are consumed or released Multi-step path ways are less efficient at generating energy

Explanation / Answer

Ans 1. B. -18.4 KJ/mol

As the ATP hydrolysis makes the reaction favourable, so the sign has to be negative (spontaneous reactions have negative gibbs energy).

The overall free energy change will be equal to the sum of free energy changes of the 2 coupled reactions

The overall free energy change = +13.8 +( -32.2) = -18.4 kj/mol

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