Which statement, if any, briefly describes the biological rationale for the allo

Question

Which statement, if any, briefly describes the biological rationale for the allosteric activation of pyruvate dehydrogenase kinase by { m NADH}. This tends to inactivate pyruvate dehydrogenase when level of { m NADH} is sufficient for { m ATP} production via the respiratory chain and, hence, to make pyruvate available for other purposes. This tends to activate pyruvate dehydrogenase when level of { m NADH} is sufficient for { m ATP} production via the cytric acid cycle and, hence, to increase the oxidation of the lipids and carbohydrates. This tends to activate pyruvate dehydrogenase when level of { m NADH} is sufficient for { m ATP} production via the respiratory chain and, hence, to make pyruvate unavailable for other purposes. None of the above

Explanation / Answer

C) correct answer -This tends to inactivate pyruvate dehydrogenase when level of NADH is sufficient for ATP production via the respiratory chain and, hence, to make pyruvate available for other purposes.

Pyruvate dehydrogenase (PDH) kinase is a part of the PDH multienzyme complex. Allosteric activation of PDH kinase by NADH causes it to phosphorylate PDH.  Phosphorylation inactivates pyruvate dehydrogenase.

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