A woman gave birth to a baby and she claims that two men in thevillage could be

Question

1. A woman gave birth to a baby and she claims that two men in thevillage could be the father of the baby. DNA was isolated from themother, baby and the suspected males. Variation at twomicrosatellite loci, located on different chromosomes, was typed.The mother’s genotypes were(AT)6/(AT)10 at the first locus and(CA)13/(CA)15 at the second locus. Thebaby’s genotypes were (AT)10/(AT)12 and(CA)7/(CA)13, respectively. The suspect maleA has genotypes (AT)8/(AT)14 and(CA)11/(CA)15. The suspect male B hasgenotypes (AT)8/(AT)12 and(CA)7/(CA)9. It is known that the frequenciesof (AT)6, (AT)8, (AT)10,(AT)12, and (AT)14 alleles in this populationare 0.05, 0.04, 0.02, 0.08 and 0.12, respectively, at the firstlocus and those of (CA)7, (CA)9,(CA)11, (CA)13 and (CA)15 allelesare 0.05, 0.15, 0.07, 0.3, and 0.04, respectively.

1. Which male suspect (A or B) is likely to be the father of thebaby? Explain.

2. Assuming Hardy-Weinberg equilibrium and linkage equilibrium*between two loci, what is the probability that a randomly chosenmale, not necessarily the suspect A and B, in this population couldbe the father of this baby? [*Linkage equilibrium means thatthe two microsatellite loci are not linked, thus the genotype inone locus is independent of the genotype in another locus]

1. A woman gave birth to a baby and she claims that two men in thevillage could be the father of the baby. DNA was isolated from themother, baby and the suspected males. Variation at twomicrosatellite loci, located on different chromosomes, was typed.The mother’s genotypes were(AT)6/(AT)10 at the first locus and(CA)13/(CA)15 at the second locus. Thebaby’s genotypes were (AT)10/(AT)12 and(CA)7/(CA)13, respectively. The suspect maleA has genotypes (AT)8/(AT)14 and(CA)11/(CA)15. The suspect male B hasgenotypes (AT)8/(AT)12 and(CA)7/(CA)9. It is known that the frequenciesof (AT)6, (AT)8, (AT)10,(AT)12, and (AT)14 alleles in this populationare 0.05, 0.04, 0.02, 0.08 and 0.12, respectively, at the firstlocus and those of (CA)7, (CA)9,(CA)11, (CA)13 and (CA)15 allelesare 0.05, 0.15, 0.07, 0.3, and 0.04, respectively.

1. Which male suspect (A or B) is likely to be the father of thebaby? Explain.

2. Assuming Hardy-Weinberg equilibrium and linkage equilibrium*between two loci, what is the probability that a randomly chosenmale, not necessarily the suspect A and B, in this population couldbe the father of this baby? [*Linkage equilibrium means thatthe two microsatellite loci are not linked, thus the genotype inone locus is independent of the genotype in another locus]

1. Which male suspect (A or B) is likely to be the father of thebaby? Explain.

2. Assuming Hardy-Weinberg equilibrium and linkage equilibrium*between two loci, what is the probability that a randomly chosenmale, not necessarily the suspect A and B, in this population couldbe the father of this baby? [*Linkage equilibrium means thatthe two microsatellite loci are not linked, thus the genotype inone locus is independent of the genotype in another locus]

Explanation / Answer

suspect male B is the father ofthe baby .

beacuse two microsatellite loci are not linked, thus thegenotype in one locus is independent of the genotype in anotherlocus

The mother’s genotypes were(AT)6/(AT)10 at the first locus and(CA)13/(CA)15 at the secondlocus.

The baby’s genotypes were(AT)10/(AT)12 and(CA)7/(CA)13, respectively.

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