Certain drugs are commonly used to study mitochondrial respiration. These drugs

Question

Certain drugs are commonly used to study mitochondrial respiration. These drugs include rotenone, oligomycin, and the mitochondrial uncoupler dinitrophenol. Rotenone inhibits the transfer of electrons from Complex I to ubiquinone, oligomycin inhibits Complex V/ATP Synthase by preventing the re­entry of protons into the matrix, and dinitrophenol leads to the uncoupling of oxidation from phosphorylation of ADP (meaning that less ATP is produced). If you were interested in studying the ATP production through glycolysisonly, which of these inhibitors would be most useful? Why?

Explanation / Answer

Answer:

Glucolysis is the process that convert glucose to pyruvate.

The agents that block gycolysis are :1) Iodoacetate: Blocks Glyceraldehyde-3-phosphate, which is produced in one of glycolysis step

2) Arsenate is an inhibitor that block the Glyceraldehyde-3-phophospate dehydrogenase, it act as an analog to phosphate

The Inhibitors such as rotenone, oligomycin, and the mitochondrial uncoupler dinitrophenol may not act in glycolysis.

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