What experimental evidence suggests that the N-terminal tails ofhistones partici

Question

What experimental evidence suggests that the N-terminal tails ofhistones participate in the formation of higher-order chromatinstructure?

a.) the tails cause the histones to denature
b.) the tails when acetylated cause the dissolution of the 30nmfibers
c.) chromatin fibers prepared with histones lacking their tailcannot fold into higher-order fibers
d.) chromatin fibers prepared with histones possessing their tailscannot fold into higher-order fibers
e.) chromatin fibers lacking their tails are shorter

Explanation / Answer

Transcriptionally active chromatin domains are associatedwith dynamically acetylated histones. The energy exhaustive processof dynamic histone acetylation has several functions. Acetylation of the N-terminal tails of the core histonesalters nucleosome and higher order chromatin structure, aidingtranscriptional elongation and facilitating the binding oftranscription factors to nucleosomes associated with regulatory DNAsequences. Histone acetylation can manipulate the interactions ofregulatory proteins that bind to the N-terminal tails of the corehistones. Lastly, dynamic acetylation may contribute to thetransient attachment of transcriptionally active chromatin to thenuclear matrix. Reversible histone acetylation is catalyzed byhistone acetyltransferase and deacetylase, enzymes associated withthe nuclear matrix. b.) the tails when acetylated cause the dissolution ofthe 30nm fibers

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