Link is : https://classes.uaa.alaska.edu/bbcswebdav/pid-6617027-dt-content-rid-2

ID: 53360 • Letter: L

Question

Link is : https://classes.uaa.alaska.edu/bbcswebdav/pid-6617027-dt-content-rid-29838327_1/courses/201503_78080/Week5%20Tumor%20suppressorsKch10.pdf

Which of the following statements about p53 is true?

Dominant negative mutations in p53 result in loss of function even in the presence of a functional p53 allele.

p53 is mutated in about 30% of all human cancers.

The presence of DNA damage causes p53 to phosphorylate ATM.

The HPV E6 oncoprotein promotes LOH at the p53 locus.

-------------------------------

Which of the following is true?

Mutation of PTEN is found in nearly 2/3 of all colon cancers.

Inherited mutations in APC result in nearly 100% risk of colon cancer by 60.

Wnt signaling normally prevents proliferation, and loss of Wnt function promotes carcinogenesis.

PTEN functions by ubiquitinating the PI3-kinase to prevent formation of PIP3.

----------------------------

Which of the following is a feature of transforming growth factor ?

TGF binds to type I and type II receptor tyrosine kinases.

TGF activates the Ras-MAPK pathway.

TGF signaling results in transcription of the Smad gene.

TGF signaling results in cell cycle arrest.

---------------------------------

Which of the following is NOT true of CDKN2A?

CDKN2A produces two different protein products that both behave as tumor suppressors.

CDKN2A shows loss of function in 15-30% of breast, lung, pancreatic and bladder cancers.

One product of CDKN2A normally promotes accumulation of p53.

CDKN2A produces two different protein products that are encoded on opposite strands of DNA.

Dominant negative mutations in p53 result in loss of function even in the presence of a functional p53 allele.

p53 is mutated in about 30% of all human cancers.

The presence of DNA damage causes p53 to phosphorylate ATM.

The HPV E6 oncoprotein promotes LOH at the p53 locus.

Which of the following statements about p53 is true?

p53 is mutated in about 30% of all human cancers.

Which of the following is true?

Inherited mutations in APC result in nearly 100% risk of colon cancer by 60.

Which of the following is a feature of transforming growth factor ?

TGF signaling results in transcription of the Smad gene.

Which of the following is NOT true of CDKN2A?

CDKN2A produces two different protein products that both behave as tumor suppressors.

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.