ack and Jill are thinking about starting a family and they come to you with a qu

Question

ack and Jill are thinking about starting a family and they come to you with a question about a rare recessive genetic disease called Alpers Syndrome. Alpers causes progressive neurodegeneration in infants and children and is usually lethal within the first 10 years of life. Jack's grandfather had a brother die of Alpers Syndrome, while Jill has no family history of the disease. If the frequency of heterozygotes for Alpers is 1 in 2000 in the general population, what is the chance that Jack and Jill will have a child with Alpers Syndrome? (Be sure to completely reduce your answer.)

Note: the answer cannot be 0.

Explanation / Answer

Jake and Jill will have 1/2 probability that their child will be a carrier. Since Jill's family don't have any family history for the disease.

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