3 . ( 2 points ). Cystic fibrosis (CF) is an autosomal recessive disease that pr

Question

3. (2 points). Cystic fibrosis (CF) is an autosomal recessive disease that primarily affects lung function, and often leads to death at an early age. A man and a woman have had two healthy children, but keep worrying that they are carriers.

3a. What is the probability of producing two healthy (non-CF) children in a row if neither parent is a carrier?

3b. What is the probability of producing two healthy (non-CF) children in a row if one of the parents is a carrier?

3c. What is the probability of producing two healthy (non-CF) children in a row if both parents are carriers?

3d. How many children would the couple have to produce in order to have 99% probability of detecting that both are, in fact, carriers?

please be very specific

Explanation / Answer

3a. The probability of producing two healthy non-CF children if neither of parent is a carrier is - 1

3b. If one of the parents is a carrier - CC X Cc; CC, Cc, CC, Cc - 1/2

3c. If both the parents are carrier - Cc X Cc CC, Cc, cC, CC - 1/2

3d. The couple have to produce two Childerns in order to have 99% probability of detecting that both are carriers

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