It has been shown that there are two distinct variants of the HIVvirus. One viru

Question

It has been shown that there are two distinct variants of the HIVvirus. One virus preferentially infects macrophages and is calledM-tropic. The other preferentially infects T cells and is calledT-tropic. The M-tropic viruses use CCR5 and CD4 as coreceptors, andthe T-tropic viruses use CXCR4 and CD4 as coreceptors. TheM-tropic viruses are found early in HIV infections; the theT-tropic viruses are found late in infections, when AIDS symptomsare prevalent. T-tropic viruses are associated with a drasticdecrease in T cells. Macrophages go to the site of wounds, wherethey are used to fight infections. T cells circulate in the bodyand fight infections at many sites.

Which receptors for HIV would you expect to find on macrophages andT cells?
a) CCR5 and CXCR4 on macrophages; CD4 and CXCR4 on T cells
b) CD4 and CXCR4 on macrophages; CXCR4 and CD4 on T cells
c) CCR5 and CD4 on macrophages; CXCR4 and CD4 on T cells
d) CXCR4 and CD4 on macrophages; CCR5 and CD4 on T cells

Explanation / Answer

The M-tropic viruses use CCR5 and CD4 as coreceptors, and theT-tropic viruses use CXCR4 and CD4 as coreceptors

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