2. (8 points) Donated blood Go amount of 2,3 bisphosphoglycerate decreases over
ID: 541377 • Letter: 2
Question
2. (8 points) Donated blood Go amount of 2,3 bisphosphoglycerate decreases over time in the RBCs in stored blood. Once tran into a patient, the stored RBC has a lower level of 2,3 BPG and would carry oxygen differently. How would the level of O2 saturation for the hemoglobin in the transfused blood compare to the patient's own blood? How would this difference effect the hemoglobin's ability to carry oxygen? (For full credit can sometimes remain metabolically active during storage. As a result, the sometimes ,:3 2.0 your answer must make use of the R-state and T-state terminology).Explanation / Answer
2,3-BPG binds perfectly with the deoxygenated hemoglobin and stabilizes the low oxygen affinity state i.e. T-state (Tensed state). Therefore, it hinders the binding of oxygen with hemoglobin. However, in stored blood, the 2,3-BPG concentration is low and hence hemoglobin will bind with dioxygen much better; when the stored blood is transfused into a patient.
Although 2,3-BPG reduces the dioxygen binding affinity of hemoglobin, it enhances the oxygen transport and releases at the tissues. Since the transfused blood has a low concentration of 2,3-BPG, hence the oxygen transport and release at the tissues will not be that effective as compared to blood with a high concentration of 2,3-BPG.
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