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Folding of a protein can be written as: D--> N, and it has a certain free energy

ID: 542363 • Letter: F

Question

Folding of a protein can be written as: D--> N, and it has a certain free energy change involved. What can you say about the free energy of stabilization of proteins? Proteins have a large free energy of stabilization, because they have to be stable for the organism to survive. Proteins have a small free energy of stabilization, because they have to change their structure if needed. Free energy of stabilization of proteins is zero, because the D> N can be reversed (Anfinsen's experiment). It is not a chemical reaction and one cannot determine the free energy of stabilization of a protein.

Explanation / Answer

First option is true. Proteins have a large free energy of stabilization so that they are stable. Low free energy of stabilization would leave them vulnerable to denaturing ie. death of organism.

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