You are studying a simple unicellular eukaryote in the lab. you observe that if

Question

You are studying a simple unicellular eukaryote in the lab. you observe that if you grow a culture of these cells(which can grow anaerobically or aerobically) without O2, they consume large amounts of glucose as they grow and they produce lactic acid from glucose. if you now supply this culture with an excess of O2, two things happen rapidly: 1) lactic acid is no longer produced 2) the rate of glucose consumption decreases even though the rate of cell growth is constant.

explain in terms of the biochemical fate of glucose and it's derivitives; what happens to the glucose if it isn't converted to lactic acid? (you do not need to list the pathway, just the key intermediates and end products).
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B) how is it that less glucose is required for the same growth rate once O2 is added?

2. You are studying a simple unicellular eukaryone in the lab. You erve than if yeu grow a eulture of ühese cells (which can grow anacrotically or serobicaly) without 02, large amounts of glucose as they grow and they peoduce lactic acid Srom the gucose. If you ow supply this culture with an excess of Oz, two thimgs happen ropidly they comaurme (1) lactic acid is no longer produced (2) the rate of glucose consumption decreases even though the take of cefl growth is constant. A) Explain (1) in terms of the bioch the glucose if it isn converted to lactic acid? (You do not need to list the entire pathway, just the key intermediates and end products) (3 points) B) How is it that less glucose is required fot the same growth rate once Op is added? (3 points)

Explanation / Answer

Based on the given data,

A)

The metabolic fate of glucose varies in aerobic and anaerobic conditions. In anaerobic glucose enter into glycolysis and gives two molecules of pyruvate. Then the 2 pyruvate molecules converted into two lactic acids by the enzyme LDH. In this condition the degradation of one glucose molecule yields only 2 ATP.

In aerobic glucose enter into glycolysis and gives two molecules of pyruvate. Then the 2 pyruvate molecules converted into two acetyl-CoA by the enzyme PDH. Now, acetyl-CoA enters into TCA cycle and converted into CO2 and H2O. In this condition the degradation of one glucose molecule yields only 36 ATP.     

B)

Thus, culture with an excess of O2 does not produce lactic acid and the rate of glucose consumption decreases, because it produce more ATP for cellular metabolism when compared to anaerobic conditions.

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