D) cooperative E) None of the answers is correct 9. Which pairs of bonds within

Question

D) cooperative E) None of the answers is correct 9. Which pairs of bonds within a peptide backbone show free rotation around both bonds A) Ca-C and N-Ca B) C-O and N-C C) C-O and N-C D) N-C and Ca-C E) N-Ca and N-C 10. Which statement is NOT correct concerning 2,3-bisphosphoglycerate (BPG)? A) It binds at a distance from the heme groups of hemoglobin B) It binds with lower affinity to fetal hemoglobin than to adult hemoglobin. C) It increases the affinity of hemoglobin for oxygen D) It is an allosteric modulator E) It is normally found associated with the hemoglobin extracted from red blood cells. Consider the oxygen-binding profle at three different pH values of 7.6, 7.4, and 7.2. Which statement is MOST correct? Hb Oxygen binding A) Curve X most likely corresponds to pH 7.2 B) Curve Z most likely corresponds to pH 7.6. C) Hb has a higher affinity for oxygen at the pH of curve 2Z. YD) Curve Y most likely corresponds to pH 7.4. E) pH has no effect on the oxygenation of 0.4 0.2 hemoglobin 20 4 60 100 120 pO2 (torr)

Explanation / Answer

9. Option D is right. in case of peptide bond amide bond (-CONH) is fixed to maintain trans orientation (N-Ca does not rotate) and C=O is unable to rotate due to higher energy is required for rotation. so, N-C and C-Ca bonds are freely rotate.

11.option D is right. affinity of hemeglobin decreases with decrease in pH. therefore, for curve X to Z to Y , pH should be decreases. so, for curve X it should be pH = 7.6, Y, pH = 7.4 and Z curve, pH = 7.2

10. option C is right.

BPG has the high affinity to bind with deoxyhemeglobin and it decrease the affinity of hemeglobin for oxygen and it acts as allosteric cofactor. it normally found with hemeglobin extracted from RBC.

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