It is imortanat for spliceosomes to remove introns precisely between the termina

Question

It is imortanat for spliceosomes to remove introns precisely between the terminal nucleotide of an intron and a first nucleotide of an exon.

It is important for spliceosomes to remove introns precisely between the terminal nucleotide of an intron and a first nucleotide of an exon. Suppose the normal junction in a pre-mRNA molecule is: 4. ...UUAGGCUAACGG... Intron Exon In this situation, the spliceosome miscleaves the pre-mRNA molecule between the C and U residues in the exon to yield the following intermediates: What are the consequences of this cleavage? (4 pts)

Explanation / Answer

Since UAA has come instead of GCU in the first codon of exon Instead of amino acid alanine it will code for stop codon (UAA). The truncated protein synthesized due to miscleaves in the pre-mRNA molecule by spliceosome will lead to dysfunction of the protein involved in the system.

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