Most of the antibody In serum is igG. Suppose we engineer a mouse gamma chain ge

Question

Most of the antibody In serum is igG. Suppose we engineer a mouse gamma chain gene and delete the hinge region. Compared with a specific wild type IgG molecule, the hinge deletion IgG with the otherwise same sequence would: Recognize a different epitope: Be unable to bind to an epitope, Bind inefficiently to surfaces bearing repeated epitopes: Recognize a more hydrophobic epitope: e Be unable to bind to an antigenic determinant, Bind epitopes promiscuously (i.e. relatively nonspecifically) EXPLAIN

Explanation / Answer

The correct options are a and e.

The hinge region deletion IgG would be unable to bind an epitope and unable to bind to an antigenic determinant.

This is because elimination of the hinge region demonstrate that the covalent linkage between hinge regions just upstream of the two CH2 domains is critical for the preservation of the IgG effector function.

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