Which of the following statements regarding an enzyme-substrate complex is not t

Question

Which of the following statements regarding an enzyme-substrate complex is not true?

      (a) The conformation of an enzyme can change upon binding of a substrate.

(b) At sufficiently high concentrations of substrate, the catalytic sites of the enzyme become filled and reaction rate reaches a maximum.

(c) It can only dissociate into enzyme and product.

(d) Enzyme-substrate complexes can be visualized by x-ray crystallography.

(e) The rate of ES formation can be decreased with a competitive inhibitor.

Explanation / Answer

(c) It can only dissociate into enzyme and product.

The ES complex has two possible fates. It can dissociate to E and S, with a rate constant k-1, or it can proceed to form product P, with a rate constant k2.

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