In most organisms, all of the glycolytic reactions occur in the cytosol. However

ID: 548019 • Letter: I

Question

In most organisms, all of the glycolytic reactions occur in the cytosol. However, in certain parasitic protozoa known as trypanosomes, the enzymes that catalyze the first seven steps of glycolysis are compartmentalized in membrane-bounded organelles called glycosomes.

Part A: What benefit do you think trypanosomes derive from this compartmentalization of glycolysis?

A)With the glycolytic enzymes compartmentalized in this way, the enzymes and intermediates in the pathway are provided with the sufficient amount of energy necessary to perform their functions.

B)With the glycolytic enzymes compartmentalized in this way, the enzymes and intermediates in the pathway can be stored under proper conditions until they are used.

C)With the glycolytic enzymes compartmentalized in this way, the enzymes and intermediates in the pathway can be maintained in the appropriate conformations and thereby they can perform their functions.

D)With the glycolytic enzymes compartmentalized in this way, the enzymes and intermediates in the pathway can be maintained in relatively high concentrations because the organellar volume is small compared to the volume of the cell.

Part B: Specific transport proteins are required to import molecules for glycolysis to occur in the glycosome. Which of the following represents a correct association between a molecule transported and the direction it would be transported – inward (into the glycosome) or outward (out of the glycosome)? Choose any that apply.

A)Glucose, inward

B)Glucose-6-phosphate, inward

C)3-phosphoglycerate, outward

D)NAD+, outward

E)Pyruvate, outward

Explanation / Answer

Part A :
The enzymes and intermediates in the pathway will be maintained at high concentrations
as the organellar volume is negligible when compared to that of volume of the cell on a whole.
So, option D) is the answer.

Part B :
Glucose moves inward, inorganicphosphate moves inward as 3-phosphoglycerate moves outward.
So Option A) and C) are the two correct options.

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In most organisms, all of the glycolytic reactions occur in the cytosol. However

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