l T-Mobile 8:16 PM × Final Project Chem 203L.pdf 1 of 3 PURIFICATION OF AN ORGAN
ID: 552109 • Letter: L
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l T-Mobile 8:16 PM × Final Project Chem 203L.pdf 1 of 3 PURIFICATION OF AN ORGANIC MIKTURE Project A startup conpany is trmig to produce its own brand of antibacterial ointment deo to analyze generic brand already on market s0 nar, make suitable modifications to the denial composition it is known that the generic ointment contains benzoic acid [the active ingredient) ben.hydrol(the fixative) ahd antiole, which adds fragrance. You are part of a development team th no separane three substances in order to determine their ointment, as well as to diacover any inactive or unlisted corstituents Some menbers ef your team were able to isolate the inactive ingredients; however, bests reveal that you stil have aminture ol benoc bod, benthydrol and anhole left unseparated Asa member of the team, you have been .nked to do the L. Design an experiment to separate the followin compounds from a mixture using any 2. Carry out characteruation studies such as meting point to confirm that your puification was suoDess Determine the percerecovery of the ind.deal components of the mat 3. re. Mixture originally contained 0Sg benaoic add 0.25g benghydrol mL anisole 10 mL diethyl ether ndvidual Pre-lab 1. The main goal purpose of the experiment is (what are you trying to discover in this labl Open with PrintExplanation / Answer
1. All this compounds are purified by column chromatography mixture of benzoic acid+ diphenyl methanol + methoxy benzene were loaded on to column according to polarity they were separated .
benzoic acid is highly polar, diphenyl methanol more polar than the methoxy benzene and methoxy benzene is nonpolar. Elueting column we get first fraction for methoxy benzene becos it is non polar less bind to silica, then obtained fraction for diphenyl methanol it is somewhat polar bind to silica hence separate as second fraction and finally more polar benzoic acid were separated it is strongly bind to silica .
2. after separation they were identified by there physical constant
melting point of benzoic acid is= 1220C
boiling point of diphenyl methanol =2980C
boiling point of methoxy benzene=253.80C
by compairing this we found that the pure compound was obtained.
3.whatwever quntity obtaned from column is concidred as percent purity
if we obtaind 0.4g of benzoic acid then given mix content 0.5 g benzoic acid
hence percent recovry is
0.5 g=100%
0.4=100 x 0.4/0.5=80% recovery of benzoic acid
similarly calculated for other two.
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