Hepatitis delta virus (HDV) has an unusual genomic structure and mode of replica
ID: 55532 • Letter: H
Question
Hepatitis delta virus (HDV) has an unusual genomic structure and mode of replication. Given what you know of HDV, fill in the following table and explain your answer.
Genomic and antigenomic RNA synthesis and mRNA transcription
Characteristic
Genomic Synthesis
Antigenomic Synthesis
mRNA transcription
1
RNA polarity (+ or -)
2
Sensitivity to a-amanitin (yes or no)
Yes
Yes
3
Small delta antigen requirement (yes or no)
4
Polymerase
5
Site of synthesis
Nucleoplasm
Nucleolus
Nucleoplasm
Characteristic
Genomic Synthesis
Antigenomic Synthesis
mRNA transcription
1
RNA polarity (+ or -)
2
Sensitivity to a-amanitin (yes or no)
Yes
Yes
3
Small delta antigen requirement (yes or no)
4
Polymerase
5
Site of synthesis
Nucleoplasm
Nucleolus
Nucleoplasm
Explanation / Answer
Characteristic
Genomic Synthesis
Antigenomic Synthesis
mRNA transcription
RNA polarity (+ or -)
Positive
Negative
Positive
Sensitivity to a-amanitin (yes or no)
Yes
Yes
No
Small delta antigen requirement (yes or no)
Yes
No
Yes
Polymerase
Takes place in nucleoplasm, mediated by RNA pol II
Occurs in nucleus, mediated by RNA pol I
occurs in nucleus, mediated by RNA pol II
Site of synthesis
Nucleoplasm
Nucleolus
NucleoplasmBottom of Form
Characteristic
Genomic Synthesis
Antigenomic Synthesis
mRNA transcription
RNA polarity (+ or -)
Positive
Negative
Positive
Sensitivity to a-amanitin (yes or no)
Yes
Yes
No
Small delta antigen requirement (yes or no)
Yes
No
Yes
Polymerase
Takes place in nucleoplasm, mediated by RNA pol II
Occurs in nucleus, mediated by RNA pol I
occurs in nucleus, mediated by RNA pol II
Site of synthesis
Nucleoplasm
Nucleolus
NucleoplasmBottom of Form
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