Version I 28) Koshland\'s induced fit model improves over Fischer\'s lock-and-ke

Question

Version I 28) Koshland's induced fit model improves over Fischer's lock-and-key model in what ways.. a) allows for flexibility of both enzyme and substrate b) allows for ability of enzymes to operate on similar substrates c) it doesn't. Fischer's model is perfect the way it is. d) (a) and (b) 29) In class, we discussed how enzymes accelerate reactions by lowering the activation energy of the transition state, How does this translate to the relative affinity of the enzyme towards free substrate versus the transition state? a) higher affinity for free substrate b) higher affinity for transition state Questions 30 and 31: Refer to the kinetic plot on the right to answer the following questions... 120 30) How would you expect the rate to change 80 if we halved the substrate concentration from 0.8u mM to 0.4 mM? 40 a) changes proportionally; saturating region b) changes proportionally; linear region c) stays essentially same; saturating region d) stays essentially same; linear region 10 20 30 40 31) How will KM change if we double the concentration of enzyme? S] (mM) a) increases by factor of 2 (doubles) b) decreases by factor of 2 (halves) c) no effect

Explanation / Answer

28.) a

Lock and Key theory is rigid when compared to induced fit theory. According to Lock and Key theory, only a certain type will fit will take place and no changes take place (active site has one single entry). As per induced fit, the active site is flexible to help to substrate fit.

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