After a rather lengthy organic chemistry synthesis procedure, a student ran the

Question

After a rather lengthy organic chemistry synthesis procedure, a student ran the product of the reaction on a plate and obtained the result below. What might he/she have done wrong, if anything? 4) A student spots an unknown sample on a TLC plate. After developing in hexanes/ethyl acetate 50:50, he/she saw a single spot with an Rf of 0.55. Does this indicate that the unknown material is a pure compound? What can be done to verify the purity of the sample? 5) Plate A, below, represents the TLC chromatogram of a compound run in hexanes. The same compound was then spotted on a large TLC plate and again run in hexanes. Which TLC plate, B, C, or D, correctly represents how far the compound would run on the longer plate? -solvent front solvent front plate D plate C plate B plate A

Explanation / Answer

TLC is qualitative method of analysis. In this case, where it is long Synthesis, no one should go with directly higher polarity mobile phase, as the separation on TLC is a function of mobile phase polarity. To get the proper picture of compound purity, one should enhance the polarity in increasing polarity manner.

In the second picture of tlc, none can't be suitable as this is in plane hexane mobile phase, as the spot separation on TLC is the function of polarity not the increase in TLC length.

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