The graph at left (modified from Kraemer, 1997. Proc. Natl. Acad. Sci. (USA) 94:

Question

The graph at left (modified from Kraemer, 1997. Proc. Natl. Acad. Sci. (USA) 94: 11–14) depicts the age of onset of skin cancers in patients with or without XP, where the cumulative percentage of skin cancer is plotted against age. The non-XP curve is based on 29,757 cancers surveyed by the National Cancer Institute, and the curve representing those with XP is based on 63 skin cancers from the Xeroderma Pigmentosum Registry.

Based on the graph, which of the following statements are true?

Select all that apply

A. For non-XP individuals, the chance of skin cancer increases as they age. B. Individuals with XP are more likely to develop skin cancer in their youth than non-XP individuals. C. At all ages, the non-XP individuals have half the rate of skin cancer as individuals with XP. D. By age 20, approximately 80% of the XP population has skin cancer. E. XP individuals almost always develop skin cancer by age 40.

Explanation / Answer

A, B, D, E are the correct answers

A. Because non-XP graph is a sigmoid curve which increases with age.

B.The XP graph is a steep graph which increases suddenly at the early age

D. Approximately 80% have skin cancer at the age of 20

E. At the age of 40 cumulative percentage is 100%

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