Sapling Learning Each of the following molecules violates Lipinski\'s rule of 5

Question

Sapling Learning Each of the following molecules violates Lipinski's rule of 5 for at least one reason. Indicate which reasons are violated for each molecule·lf there is more than one answer, select all that apply. NH N OH 0 k = 365.51 log(P) -5.4 695.80 log(P) = 2.7 “ = 462.41 log(P) = 1.2 Too many H-bond donors Too many H-bond acceptors Too big Too hydrophobic Too many H-bond donors [] Too many H-bond donors Too many H-bond acceptors l Too big Too hydrophobic Too many H-bond acceptors | Too big Too hydrophobic

Explanation / Answer

In molecule 1-

In molecule 2-

In molecule 3 -

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