Which of the following features should an effective transition state analog inhi

Question

Which of the following features should an effective transition state analog inhibitor have (select all that apply)? (Hint: be sure you know what type of inhibitor transition state analogs are, and then identify which features enhance the behavior of that type of inhibitor.)

Being small enough that the substrate can also still bind to the enzyme

The same overall charge as residues present in the active site

The ability to covalently bond to an active site residue

Interactions with the residues that stabilize the substrate

Interactions with the residues that stabilize the transition state (hint: this is not the same thing as actually binding to the transition state; again keep in mind the type of inhibitor)

Being small enough that the substrate can also still bind to the enzyme

The same overall charge as residues present in the active site

The ability to covalently bond to an active site residue

Interactions with the residues that stabilize the substrate

Interactions with the residues that stabilize the transition state (hint: this is not the same thing as actually binding to the transition state; again keep in mind the type of inhibitor)

Explanation / Answer

The correct opotion is Interactions with the residues that stabilize the transition state.

Reason: The transtion state of inhibitor resembles to the binding site of substrate transtion state and binds to the enzyme. It binds so strongly.

Related Questions

Navigate

• Browse (All)
• Browse W
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.