2,3-biphosphoglycerate (BPG) regulates high... 1. (2 pts) 2,3-biphosphoglycerate

Question

2,3-biphosphoglycerate (BPG) regulates high...

1. (2 pts) 2,3-biphosphoglycerate (BPG) regulates high altitude adaptation. The BPG concentration increases from 5 mM at sea level to 8 mM at an altitude of 4500 meters in human blood. Please explain how our blood manages to transport enough oxygen at high altitude according to the binding curve below. If the BPG concentration does not change, how much less oxygen can the blood transport at 4500 meters compared to that at sea level? A mutation of hemoglobin reduces the binding affinity of BPG, how will this mutation affect oxygen binding and the Hill's coefficient? pO2 in lungs po in po, in lungs tissues (4,500 m)Isea levell 1.0 Y o.s BPG 5 mm 12 16 po2 (kPa)

Explanation / Answer

BPG helps in increasing the affinity of Hb's O2 binding capacity. At higher altitude, since the number of BPG increases, every time it cleaves off from Hb, more O2 affinity increases.

Binding of BPG with the beta chains of Hb is the key to O2 affinity of Hb. When BCG leaves Hb centre, then only O2 is able to bind with greater affinity. If there is mutation in BCG binding, there will be decreased O2 binding as well.

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