The following diagram represents two nonhomologous chromosomes in the diploid ce

Question

The following diagram represents two nonhomologous chromosomes in the diploid cells of an organism. Note: the * indicates the centromere.

            A B * C D E F G H

            R S * T U V W X

Another cell from this same individual is found to contain the chromosomes below. The homologues for these two chromosomes are normal. What type of chromosomal mutation is most likely to have occurred?

            A B * C D E F G H

            R S * T U V G W X

a.paracentric inversion

b.nonreciprocal translocation

c.displaced duplication

d.interstitial deletion

e.none of the above – this type of change is not possible

Explanation / Answer

Observing the two sequences clearly shows us that it is a deletion mutation. Of the four options, given only one deletion mutation, i.e., interstitial deletion. Interstitial deletions are those that occur from the interior of a chromosome, and not from the terminal ends. Carefully observing the two sequences makes us know that it is interstitial deletion, as G, which is in the middle of the chromosome, got missed.

A B * C D E F G H / R S * T U V G W X represents normal gene alignment on respective chromosme, while A B * C D E F G H / R S * T U V W X shows interstitial deletion of G base. Thus, the correct answer is option (d) interstitial deletion.

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