meications are formulated such that there is a slow release of the active ingred
ID: 564265 • Letter: M
Question
meications are formulated such that there is a slow release of the active ingredients. Such formulations are known as "extended release." Azithromycin ER is a single-dose, extended release formulation. The recommended dosage for a child 6 months and older who is brought to the Emergency Room with community acquired pneumonia is 60 mg/kg administered orally. Azithromycin (immediate release) has much faster onset of action and acts almost immediately when administered intravenously (by IV). Clinicians exercise clinical judgment when deciding whether or not to treat a pediatric patient with azithromycin intravenously. If therapy is deemed necessary, a dose of 10 mg/kg for those age 6 months to 16 years is considered reasonable. a) Based on the information above, what would be an appropriate dose of azithromycin ER for a baby weighing 17 Ibs such as Amaan? (oomal b) How does the appropriate dose of azithromycin ER for a baby weighing 17 lbs such as Amaan compare with the dose of azithromycin that was given intravenously to Amaan. c) What would be an appropriate dose of azithromycin (immediate release) administered by IV for a baby weighing 17 lbs such as Amaan? How does your calculated dose compare with that indicated by Dr.Loiselle?Explanation / Answer
a) 1 lb = 0.4536 Kg
Therefore, 17 lb = 17*0.4536 Kg = 7.711 Kg
The recommended dose = 60 mg per 1 Kg
Therefore, per 7.711 Kg, the appropriate dose of azithromycin ER = 7.711*60 mg = 462.66 mg
b) It is almost near to 500 mg, i.e. almost the same.
c) The reasonable dose for those age 6 months to 16 years = 10 mg per 1 Kg
Therefore, per 7.711 Kg, the reasonable dose of azithromycin ER = 7.711*10 mg = 77.11 mg
Dr. Loiselle indicated that the 500 mg dosage administered for Amaan is more typical for an adult and not a 17-pound baby.
Hence the calculated dose was much less than that indicated by Dr. Loiselle. i.e. 77.11 mg << 500 mg
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