Which of the following is correct? COPII vesicles transport proteins from the Ci

Question

Which of the following is correct?

COPII vesicles transport proteins from the Cis-Golgi to the trans-Golgi

COPI vesicles transport proteins from the Cis-Golgi to the trans-Golgi

COPI vesicles transport proteins from the Cis-Golgi to the ER

COP I vesicles transport proteins from the trans-Golgi to the late endosome

COPII vesicles transport proteins from the Cis-Golgi to the trans-Golgi

COPI vesicles transport proteins from the Cis-Golgi to the trans-Golgi

COPI vesicles transport proteins from the Cis-Golgi to the ER

COP I vesicles transport proteins from the trans-Golgi to the late endosome

Explanation / Answer

COPI vesicles transport proteins from the Cis-Golgi to the ER: correct

COPI is a protein complex that coats vesicles transporting proteins from the cis end of the Golgi complex back to the rough endoplasmic reticulum (ER), where they were originally synthesized, and between Golgi compartments. This type of transport is termed as retrograde transport, in contrast to the anterograde transportassociated with the COPII protein. The name "COPI" refers to the specific coat protein complex that initiates the budding process on the cis-Golgi membrane. The coat consists of large protein subcomplexes that are made of seven different protein subunits.COPI-coated vesicles bud from the ER-Golgi intermediate compartment or the Golgi apparatus and function in the retrieval pathways that serve to retain resident proteins in the Golgi and ER. For example, COPI-coated vesicles transport resident ER proteins marked by the KDEL or KKXX retrieval signals back to the ER from the ER-Golgi intermediate compartment or thecis Golgi network.

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