Ceramic nanoparticles . Describe some of the different ways this nanoparticle co
ID: 56531 • Letter: C
Question
Ceramic nanoparticles . Describe some of the different ways this nanoparticle could be functionalized to accumulate in type 1 diabetes tissue . Would it be more beneficial to perform active or passive targeting? If you were to perform active targeting, what are 3 different tissue biomarkers you would try to target, and why? What sorts of targeting molecules would you put on the surface of your nanoparticle? What are your most important considerations when picking targeting molecules (size, charge, affinity, etc)? How do you expect this active targeting to change your overall nanoparticle accumulation in your tissue? If you were to perform passive targeting, what physical properties of your nanoparticle would you optimize, and why? How do you expect this passive targeting to change your overall nanoparticle accumulation in your tissue?
Explanation / Answer
The nanoparticle could be used for cell labelling and tracking , it can be used to increase the blood pool in type 1 diabetes tissue . It can be used to release insulin when the blood sugar level increases which can be mapped by the nanoparticle.
Active targeting would be more beneficial because the nanoparticle would interact directly with the tissue.
If you were to perform active targeting, 3 different tissue biomarkers you would try to target are Target biomarkers which identify the target tissue , Mechanism biomarkers which help in knowing the physiological changes that occur and Toxicity biomarkers which indicate the levels of toxin.
On the surface it would be Synthetic polymers which make it more soluble and able to carry the product. Also PolyEthyleneGlycol can be used .
Targeting size will depend on the size , charge and affinity of target molecules. The size has to be small and the charge would depend upon its interaction with the tissue that provides the affinity of the target molecule for a particular portion of a tissue and a drug it is carrying.
Active targeting is much better option for nanoparticle accumulation because there is less chance of improper release of drugs because it contacts directly with the concerned tissue.
Passive targeting would be possible if we consider certain physical properties of nanoparticles such as ability to release drugs without in contact with the specific tissue , ability of the particle to direct a drug to the specific point of the tissue. Ability to track the process and find faults in the process.
Passive targeting decreases the overall nanoparticle accumulation in the tissue because mainly of improper contact of the nanoparticle with the tissue which leads to the decrease in release of drugs by the nanoparticle in the specific tissue.
Related Questions
drjack9650@gmail.com
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.