biochemistry Which are the following true regarding Levinthafs Paradox: This was
ID: 56847 • Letter: B
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biochemistry Which are the following true regarding Levinthafs Paradox: This was a thought experiment. Levinthal noticed that because of the very large number of degrees of freedom in an unfolded polypeptide chain, the molecule has an astronomical number of possible conformations. For example, a polypeptide of 100 residues will have 99 peptide II bonds, and therefore 198 different phi and psi bond angles Therefore if a protein were to attain its correctly folded configuration by sequentially sampling all the possible conformations, it would require a time longer than the age of the universe to arrive at its correct native conformation The "paradox" is that most small proteins fold spontaneously on a millisecond or even microsecond time scale The paradox can be resolved if partially correct intermediates are retained during the protein folding process The paradox refers to the fact that most proteins require chaperones to fold.Explanation / Answer
1. Levinthal noticed that because of the very large number of degrees of freedon in an unfolded polypeptide chain, the molecule has an astronomical number of possible conformations. For example, a polypeptide of 100 residues will have 99 peptide bonds,......--------> TRUE
2. The paradox is that most small proteins fold spontaneously on a millisecond or even microsecond time scale ---------------> TRUE.
3. The paradox can be resolved if partially correct intermediates are retained during the protein folding process. ------> TRUE
4. The paradox refers to the fact that most proteins require chaperones to fold. ---------> FALSE (Some proteins do not require chaperons to fold).
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