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M8. Below is a schematic for using a gold-silica nanoshell for cancer diagnostic

ID: 57024 • Letter: M

Question

M8.

Below is a schematic for using a gold-silica nanoshell for cancer diagnostics and therapy. Describe how this works. The data on the next page perhaps attest to its potential efficacy (comment on this).   To my knowledge (perhaps not current), this approach has only been demonstrated in lab rats with tumors. Search if there has been any recent human trials for such, and report back. Explain answer.

100% 90% | B096 70% 60% 50% 40% 30% 20% 10% 0% Nanoshell Therapy (n=7) 100% survival for Nanoshell Therapy Binding ligands Gold-silica nanoshell Oncoproteins Tumor cell surface aser only group (n-8 controlI roup In-9) Day after tumor treatment ne www.tert.o

Explanation / Answer

Gold-silica nanoshells contain nanoparticles that which are capable to detect and treat a certain disease such as cancer. These nanoparticles have small size and large optical properties. These gold-silica nanoshells are inserted into tumors by the process of Phagocytosis which engulf the nanoshell. These nanoshells then reach the particular cell and is metabolized by enzymes . It releases certain infra-red illumination in order to kill the tumor and to stop its spreading.

Human trials have occured in order to treat cancer with malignant tumor . These nanoshells where inserted into the body through phagocytosis at the tumor of interest. These nanoshells use their optical properties in which they release infrared illumination necessary to kill the tumor